Parisi MA, Baladessari AE, Iida MH, Clarke CM, Doggett B, Shirasawa S, Kapur RP. Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/-mice. Gastroenterology, 125(5):1428-1440, 2003.
Klampfer L, Huang J, Corner G, Mariadasin J, Arango D, Sasazuki T,Shirasawa S, Augenlicht L. Oncogenic k-ras inhibits the expression of IFN-responsive genes through inhibition of STAT1 and STAT2 expression. J. Biol.Chem., 278(47):46278-46287, 2003.
Klampfer L, Huang J, Sasazuki T, Shirasawa S, Augenlicht L. Inhibition of IFN-gamma signaling by the short chain fatty acid butyrate. Mol. Cancer Res., 1(11):855-862, 2003.
Long IS, Han K, Li M, Shirasawa S, Sasazuki T, Johnston M, Tsao MS. Met Receptor Overexpression and Oncogenic Ki-ras Mutation Cooperate to Enhance Tumorigenicity of Colon Cancer Cells in Vivo. Mol. Cancer Res., 1(5):393-401, 2003.
Shirasawa S and Sasazuki T. The impact of oncogenes on tumor maintenance. Oncogene-Directed Therapies (Rak JW Ed., Human Press Inc., Totowa), 229-243, 2002.
Tsunoda T, Inokuchi J, Baba I, Okumura K, Naito S, Sasazuki T, Shirasawa S. A Novel Mechanism of Nuclear Factor kappaB Activation through the Binding between Inhibitor of Nuclear Factor-kappaBalpha and the Processed NH(2)-terminal Region of Mig-6. Cancer Res., 62(20): 5668-5671, 2002.
Qian Y, Shirasawa S, Chen CL, Cheng L, Ma Q. Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes Dev., 16(10): 1220-1233, 2002.
Kanai M, Numakura C, Sasaki A, Shirahata, E, Akaba, K, Hashimoto M, Hasegawa, H, Shirasawa S, Hayasaka K. Congenital central hypoventilation syndrome: a novel mutation of the RET gene in an isolated case. Tohoku J. Exp. Med., 196:241-246, 2002
Qian Y, Fritzsch B, Shirasawa S, Chen CL, Choi Y, Ma Q. Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev., 15: 2533-2545., 2001.
Sakai K, Shirasawa S, Ishikawa N, Ito K, Tamai H, Kuma K, Akamizu T, Tanimura M, Furugaki K, Yamamoto K, Sasazuki T. Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese. Hum. Mol. Genet., 10: 1379-1386, 2001.
Habets GG, Knepper M, Sumortin J, Choi YJ, Sasazuki T, Shirasawa S, Bollag G. cDNA array analyses of K-ras-induced gene transcription. Methods Enzymol., 332: 245-260, 2001.
Baba I, Shirasawa S, Iwamoto R, Okumura K, Tsunoda T, Nishioka M, Fukuyama K,Yamamoto K, Mekada E, Sasazuki T. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells. Cancer Res., 60(24): 6886-6889, 2000.
Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell, 103(2): 321-330, 2000.
Shirasawa S, Arata A, Onimaru H, Roth KA, Brown GA, Horning S, Arata S, Okumura K, Sasazuki T, Korsmeyer SJ. Rnx deficiency results in congenital central hypoventilation. Nature Genet., 24(3): 287-290, 2000.
Allgayer H, Wang H, Shirasawa S, Sasazuki T, Boyd D. Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen- dependent proteolysis. Br. J. Cancer, 80(12): 1884-1891, 1999.
Okumura K, Shirasawa S, Nishioka M, Sasazuki T. Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate- induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.Cancer Res., 59(10): 2445-2450, 1999.
Okada F, Rak JW, Croix BS, Lieubeau B, Kaya M, Roncari L, Shirasawa S, Sasazuki T, Kerbel RS. Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc. Natl. Acad. Sci. USA , 95(7): 3609-3614, 1998.
Savoie CJ, Kamikawaji N, Sudo T, Furuse M, Shirasawa S, Tana T, Sasazuki T. MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line. Cancer Lett., 123(2): 193-197, 1998.
Shirasawa S, Yunker AM, Roth KA, Brown GA, Horning S, Korsmeyer SJ. Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon. Nature Med., 3(6): 646-650, 1997.
Ohmori M, Shirasawa S, Furuse M, Okumura K, Sasazuki T. Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells. Cancer Res., 57(21): 4714-4717, 1997.
Furuse M, Shirasawa S, Okumura K, Ohmori M, Sasazuki T. Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells. Jpn. J. Human Genet., 42:409-416, 1997.
Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, Kerbel RS. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res., 55(20): 4575-4580, 1995.
Shirasawa S, Furuse M, Yokoyama N, Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science, 260(5104): 85-88, 1993.
Shirasawa S, Urabe K, Yanagawa Y, Toshitani K, Iwama T, Sasazuki T. p53 gene mutations in colorectal tumors from patients with familial polyposis coli. Cancer Res., 51(11): 2874-2878, 1991.
Klampfer L, Huang J, Corner G, Mariadasin J, Arango D, Sasazuki T,Shirasawa S, Augenlicht L. Oncogenic k-ras inhibits the expression of IFN-responsive genes through inhibition of STAT1 and STAT2 expression. J. Biol.Chem., 278(47):46278-46287, 2003.
Klampfer L, Huang J, Sasazuki T, Shirasawa S, Augenlicht L. Inhibition of IFN-gamma signaling by the short chain fatty acid butyrate. Mol. Cancer Res., 1(11):855-862, 2003.
Long IS, Han K, Li M, Shirasawa S, Sasazuki T, Johnston M, Tsao MS. Met Receptor Overexpression and Oncogenic Ki-ras Mutation Cooperate to Enhance Tumorigenicity of Colon Cancer Cells in Vivo. Mol. Cancer Res., 1(5):393-401, 2003.
Shirasawa S and Sasazuki T. The impact of oncogenes on tumor maintenance. Oncogene-Directed Therapies (Rak JW Ed., Human Press Inc., Totowa), 229-243, 2002.
Tsunoda T, Inokuchi J, Baba I, Okumura K, Naito S, Sasazuki T, Shirasawa S. A Novel Mechanism of Nuclear Factor kappaB Activation through the Binding between Inhibitor of Nuclear Factor-kappaBalpha and the Processed NH(2)-terminal Region of Mig-6. Cancer Res., 62(20): 5668-5671, 2002.
Qian Y, Shirasawa S, Chen CL, Cheng L, Ma Q. Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes Dev., 16(10): 1220-1233, 2002.
Kanai M, Numakura C, Sasaki A, Shirahata, E, Akaba, K, Hashimoto M, Hasegawa, H, Shirasawa S, Hayasaka K. Congenital central hypoventilation syndrome: a novel mutation of the RET gene in an isolated case. Tohoku J. Exp. Med., 196:241-246, 2002
Qian Y, Fritzsch B, Shirasawa S, Chen CL, Choi Y, Ma Q. Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev., 15: 2533-2545., 2001.
Sakai K, Shirasawa S, Ishikawa N, Ito K, Tamai H, Kuma K, Akamizu T, Tanimura M, Furugaki K, Yamamoto K, Sasazuki T. Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese. Hum. Mol. Genet., 10: 1379-1386, 2001.
Habets GG, Knepper M, Sumortin J, Choi YJ, Sasazuki T, Shirasawa S, Bollag G. cDNA array analyses of K-ras-induced gene transcription. Methods Enzymol., 332: 245-260, 2001.
Baba I, Shirasawa S, Iwamoto R, Okumura K, Tsunoda T, Nishioka M, Fukuyama K,Yamamoto K, Mekada E, Sasazuki T. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells. Cancer Res., 60(24): 6886-6889, 2000.
Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell, 103(2): 321-330, 2000.
Shirasawa S, Arata A, Onimaru H, Roth KA, Brown GA, Horning S, Arata S, Okumura K, Sasazuki T, Korsmeyer SJ. Rnx deficiency results in congenital central hypoventilation. Nature Genet., 24(3): 287-290, 2000.
Allgayer H, Wang H, Shirasawa S, Sasazuki T, Boyd D. Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen- dependent proteolysis. Br. J. Cancer, 80(12): 1884-1891, 1999.
Okumura K, Shirasawa S, Nishioka M, Sasazuki T. Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate- induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.Cancer Res., 59(10): 2445-2450, 1999.
Okada F, Rak JW, Croix BS, Lieubeau B, Kaya M, Roncari L, Shirasawa S, Sasazuki T, Kerbel RS. Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc. Natl. Acad. Sci. USA , 95(7): 3609-3614, 1998.
Savoie CJ, Kamikawaji N, Sudo T, Furuse M, Shirasawa S, Tana T, Sasazuki T. MHC class I bound peptides of a colon carcinoma cell line, a Ki-ras gene-targeted progeny cell line and a B cell line. Cancer Lett., 123(2): 193-197, 1998.
Shirasawa S, Yunker AM, Roth KA, Brown GA, Horning S, Korsmeyer SJ. Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon. Nature Med., 3(6): 646-650, 1997.
Ohmori M, Shirasawa S, Furuse M, Okumura K, Sasazuki T. Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells. Cancer Res., 57(21): 4714-4717, 1997.
Furuse M, Shirasawa S, Okumura K, Ohmori M, Sasazuki T. Suppression of serum-induced c-jun expression by activated Ki-ras in human colon cancer cells. Jpn. J. Human Genet., 42:409-416, 1997.
Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, Kerbel RS. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res., 55(20): 4575-4580, 1995.
Shirasawa S, Furuse M, Yokoyama N, Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science, 260(5104): 85-88, 1993.
Shirasawa S, Urabe K, Yanagawa Y, Toshitani K, Iwama T, Sasazuki T. p53 gene mutations in colorectal tumors from patients with familial polyposis coli. Cancer Res., 51(11): 2874-2878, 1991.