Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P,Shirasawa S, Goulding M, Ma Q. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat. Neurosci., 8(11):1510-5, 2005
Sugiyama S, Nakabayashi K, Baba I, Sasazuki T,Shirasawa S. Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. Biochem. Biophys. Res. Commun. ,337(1):271-4, 2005
Shahrzad S, Quayle L, Stone C, Plumb C,Shirasawa S, Rak JW, Coomber BL. Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression. Cancer Res., 65(18):8134-41, 2005
Pollock CB, Shirasawa S,Sasazuki T, Kolch W, Dhillon AS. Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. Cancer Res., 65(4):1244-50, 2005
Drosopoulos KG , Roberts ML, Cermak L, Sasazuki T, Shirasawa S, Andera L, and Pintzas A. Transformation by oncogenic Ras sensitizes human colon cells to trail induced apoptosis by upregulating DR4 and DR5 through a MEK-dependent pathway. J. Biol. Chem., 280(24):22856-67, 2005
Klampfer L, Swaby L-A, Huang J, Sasazuki T, Shirasawa S, Augenlicht L. Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis. Oncogene, 24(24):3932-41, 2005
Hiratani H, Bowden DW, Ikegami S, Shirasawa S, Shimizu A, Iwatani Y, Akamizu T. Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J. Clin. Endocrinol. Metab., 90(5):2898-903, 2005
Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae S-C, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K. A functional variant in FcRH3, encoding Fc Receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nature Genet., 37(5):478-85, 2005
Caron RW, Yacoub A, Mitchell C, Zhu X, Hong Y, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P. Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.Cell Cycle , 4(3):456-64, 2005
Caron RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasasuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Activated forms of H-RAS and K-RAS differentially regulate membrance association of PI3K, PDK-1 and AKT and the impact of therapeutic kinase inhibitors on cell survival. Mol. Cancer Ther., 4(2):257-70, 2005
Caron RW, Yacoub A, Zhu X, Mitchell C, Han SI, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P. H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. Mol. Cancer Ther. , 4(2):243-55, 2005
Mabuchi R, Sasazuki T, Shirasawa S. Mapping of the critical region of mitogene-inducible gene-6 for NK-kappaB activation. Oncol. Rep., 13(3):473-6, 2005
Yu JL, May L, Lhotak V, Shahrzad S, Shirasawa S, Weitz JI, Coomber BL, Mackman N, Rak JW. Oncogenic events regulate tissue factor expression in colorectal cancer cells:Implications for tumor progression and angiogenesis. Blood, 105(4):1734-41, 2005
Sugiyama S, Nakabayashi K, Baba I, Sasazuki T,Shirasawa S. Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. Biochem. Biophys. Res. Commun. ,337(1):271-4, 2005
Shahrzad S, Quayle L, Stone C, Plumb C,Shirasawa S, Rak JW, Coomber BL. Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression. Cancer Res., 65(18):8134-41, 2005
Pollock CB, Shirasawa S,Sasazuki T, Kolch W, Dhillon AS. Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. Cancer Res., 65(4):1244-50, 2005
Drosopoulos KG , Roberts ML, Cermak L, Sasazuki T, Shirasawa S, Andera L, and Pintzas A. Transformation by oncogenic Ras sensitizes human colon cells to trail induced apoptosis by upregulating DR4 and DR5 through a MEK-dependent pathway. J. Biol. Chem., 280(24):22856-67, 2005
Klampfer L, Swaby L-A, Huang J, Sasazuki T, Shirasawa S, Augenlicht L. Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis. Oncogene, 24(24):3932-41, 2005
Hiratani H, Bowden DW, Ikegami S, Shirasawa S, Shimizu A, Iwatani Y, Akamizu T. Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J. Clin. Endocrinol. Metab., 90(5):2898-903, 2005
Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae S-C, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K. A functional variant in FcRH3, encoding Fc Receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nature Genet., 37(5):478-85, 2005
Caron RW, Yacoub A, Mitchell C, Zhu X, Hong Y, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P. Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.Cell Cycle , 4(3):456-64, 2005
Caron RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasasuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Activated forms of H-RAS and K-RAS differentially regulate membrance association of PI3K, PDK-1 and AKT and the impact of therapeutic kinase inhibitors on cell survival. Mol. Cancer Ther., 4(2):257-70, 2005
Caron RW, Yacoub A, Zhu X, Mitchell C, Han SI, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P. H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. Mol. Cancer Ther. , 4(2):243-55, 2005
Mabuchi R, Sasazuki T, Shirasawa S. Mapping of the critical region of mitogene-inducible gene-6 for NK-kappaB activation. Oncol. Rep., 13(3):473-6, 2005
Yu JL, May L, Lhotak V, Shahrzad S, Shirasawa S, Weitz JI, Coomber BL, Mackman N, Rak JW. Oncogenic events regulate tissue factor expression in colorectal cancer cells:Implications for tumor progression and angiogenesis. Blood, 105(4):1734-41, 2005