主要論文

Ishikura S, Nagai M, Tsunoda T, Nishi K, Tanaka Y, Koyanagi M, Shirasawa S. : The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes. J Cell Biochem, doi: 10.1002/jcb.29890, 2021
Ishikura S, Nakabayashi K, Nagai M, Tsunoda T, Shirasawa S. : ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B–H4K8ac–BRD4 axis. Nucleic Acids Res, 48(19):10848-10866, 2020
Nishi K, Iwaihara Y, Tsunoda T, Doi K, Sakata T, Shirasawa S, Ishikura S. ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line. Cell Death Dis, 14;8(12):3218, 2017
Ishikura S, Tsunoda T, Nakabayashi K, Doi K, Koyanagi M, Hayashi K, Kawai T, Tanaka Y, Iwaihara Y, Luo H, Nishi K, Okamura T, Shirasawa S. Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells. Biochim Biophys Acta, 1859(11):1398-1410, 2016
Ishikura S, Iwaihara Y, Tanaka Y, Luo H, Nishi K, Doi K, Koyanagi M, Okamura T, Tsunoda T, Shirasawa S. The nuclear zinc finger protein Zfat maintains FoxO1 protein levels in peripheral T cells by regulating activities of autophagy and Akt signaling pathway. J Biol Chem, 291(29):15282-15291, 2016
Yoo BH, Zagryazhskaya A, Li Y, Koomson A, Khan IA, Sasazuki T, Shirasawa S, Rosen K. Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells. Autophagy, 11(8):1230-1246, 2015
Sun Q, Luo T, Ren Y, Florey O, Shirasawa S, Sasazuki T, Robinson DN, Overholtzer M. Competition between human cells by entosis. Cell Res, 24(11):1299-1310, 2014
Vartanian S, Bentley C, Brauer MJ, Li L, Shirasawa S, Sasazuki T, Kim JS, Haverty P, Stawiski E, Modrusan Z, Waldman T, Stokoe D. Identification of mutant KRas-dependent phenotypes using a panel of isogenic cell lines. J Biol Chem, 288(4): 2403-2413, 2013
Liu N, Matsumoto M, Kitagawa K, Kotake Y, Suzuki S, Shirasawa S, Nakayama KI, Nakanishi M, Niida H, Kitagawa M. Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling. EMBO J, 31(10):2365-2377, 2012
Van Schaeybroeck S, Kyula JN, Fenton A, Fenning CS, Sasazuki T, Shirasawa S, Longley DB, Johnston PG. Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17. Cancer Res., 71(3):1071-1080, 2011
Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, Russo M, Cancelliere C, Zecchin D, Mazzucchelli L, Sasazuki T, Shirasawa S, Geuna M, Frattini M, Baselga J, Gallicchio M, Biffo S, Bardelli A. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J Clin Invest., 120(8):2858-2866, 2010
Tsunoda T, Takashima Y, Tanaka Y, Fujimoto T, Doi K, Hirose Y, Koyanagi M, Yoshida Y, Okamura T, Kuroki M, Sasazuki T, Shirasawa S. Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands. Proc Natl Acad Sci USA, 107(32):14199-14204, 2010
She QB, Halilovic E, Ye Q, Zhen W, Shirasawa S, Sasazuki T, Solit DB, Rosen N. 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell, 18(1):39-51, 2010
Fujimoto T, Miyasaka K, Koyanagi M, Tsunoda T, Baba I, Doi K, Ohta M, Kato N, Sasazuki T, Shirasawa S. Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. PLoS ONE., 4(1):e4240, 2009
Koyanagi M, Nakabayashi K, Fujimoto T, Gu N, Baba I, Takashima Y, Doi K, Harada H, Kato N, Sasazuki T, Shirasawa S. ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes. Genomics, 91(5):451-7, 2008
Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P, Shirasawa S, Goulding M, Ma Q. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nature Neurosci., 8(11):1510-1515, 2005
Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae S-C, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K. A functional variant in FcRL3, encoding Fc Receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nature Genet. 37 (5):478-485, 2005
Yu JL, May L, Lhotak V, Shahrzad S, Shirasawa S, Weitz JI, Coomber BL, Mackman N, Rak JW. Oncogenic events regulate tissue factor expression in colorectal cancer cells:Implications for tumor progression and angiogenesis. Blood, 105(4):1734-1741, 2005
Shirasawa S, Sugiyama S, Baba I, Inokuchi J, Sekine S, Ogino K, Kawamura Y, Dohi T, Fujimoto M, Sasazuki T. Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc. Natl Acad. Sci. USA , 101(38):13921-13926, 2004
Shirasawa S, Harada H, Furugaki K, Akamizu T, Ishikawa N, Ito K, Ito K, Tamai H, Kuma K, Kubota S, Hiratani H, Tsuchiya T, Baba I, Ishikawa M, Tanaka M, Sakai K, Aoki M, Yamamoto K, Sasazuki T. SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT , determine susceptibility to autoimmune thyroid disease. Hum. Mol. Genet., 13(19):2221-2231, 2004
Cheng L, Arata A, Mizuguchi R, Qian Y, Karunaratne A, Gray PA, Arata S, Shirasawa S, Bouchard M, Luo P, Chen CL, Busslinger M, Goulding M, Onimaru H, Ma Q. TLx3 and TLx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nature Neurosci., 7(5):510-517, 2004
Shirasawa S, Sasazuki T. The impact of oncogenes on tumor maintenance. Oncogene-Directed Therapies (Rak JW. Ed., Human Press Inc., Totowa):229-243, 2002
Qian Y, Shirasawa S, Chen C, Cheng L, Ma Q. Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes Dev., 16: 1220-1233, 2002
Qian Y, Fritzsch B, Shirasawa S, Chen CL, Choi Y, Ma Q. Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev., 15: 2533-2545, 2001
Sakai K, Shirasawa S, Ishikawa N, Ito K, Tamai H, Kuma K, Akamizu T,Tanimura M, Furugaki K, Yamamoto K, Sasazuki T. Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese. Hum. Mol. Genet., 10: 1379-1386, 2001
Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell, 103(2): 321-330, 2000
Shirasawa S, Arata A, Onimaru H, Roth KA, Brown GA, Horning S, Arata S, Okumura K, Sasazuki T, Korsmeyer SJ. Rnx deficiency results in congenital central hypoventilation. Nature Genet., 24(3): 287-290, 2000
Shirasawa S, Yunker AM, Roth KA, Brown GA, Horning S,Korsmeyer SJ. Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon. Nature Med., 3(6): 646-650, 1997
Shirasawa S, Furuse M, Yokoyama N,Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science, 260(5104): 85-88, 1993

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